Figure 3.

Plasma Concentrations of REP 2139 and REP 2165 in the Cynomolgus Monkey

(A and B) NAP clearance kinetics in cynomolgus monkey plasma following the first i.v. bolus injection (A) and NAP concentrations in mouse plasma 24 hr after injection on various days during chronic dosing (B). Dotted lines indicate lower limit of quantification (LLOQ; 10 ng/mL). Values less than the LLOQ (10 ng/mL) were set to 5 ng/mL for calculation of mean and SD. Plotted values = mean ± SD (n = 8–10 [1:1 male:female]). Asterisks (*) indicate statistically significant difference between REP 2139 (black bars/markers) and REP 2165 (white bars/markers) (p < 0.05) as determined by t test.