Figure 5.

Tissue Concentrations of REP 2139 and REP 2165 in the Cynomolgus Monkey

(A) Concentrations of NAPs in monkey kidney (top) and liver (bottom) after 26 weeks of dosing. (B) Concentrations of NAPs 6 weeks after the end of treatment (EOT) following dosing at 27 mg/kg in cynomolgus kidney (top) and liver (bottom). Plotted values = mean ± SD. (A) n = 3–6 (1:1 male:female); (B) n = 4 (2 male, 2 female). Asterisks (*) indicate statistically significant difference between REP 2139 (black bars) and REP 2165 (white bars) (p < 0.05) as determined by t test.