Figure 6.

NAP Serum and Tissue Distribution in the Pekin Duck

(A) Concentrations of REP 2139 in uninfected duck serum (ng/mL), liver (ng/g), and kidney (ng/g) following a single bolus i.p. administration (9 mg/kg). (B) Body weight in DHBV-infected ducks treated with various NAPs. No statistically significant differences in body weight were observed relative to the saline control group. (C) Liver concentrations of various NAPs after completion of 3 weeks of dosing 10 mg/kg three times per week (see Materials and Methods). All plotted values represent mean ± SD. (A) n = 3; (B and C) n = 5. (C) Asterisks (*) indicate statistically significant difference between liver accumulation of REP 2139 and other NAPs (p < 0.05) as determined by t test.