Figure 7.

On-Treatment In Vivo Effects of Various NAPs on Serum and Liver Viremia in DHBV-Infected Pekin Ducks

(A–D) In vivo effects of various NAPs on (A) serum DHBsAg, (B) serum DHBV DNA, (C) liver DHBV DNA, and (D) liver cccDNA in established DHBV infection in Pekin ducks after 14 days of daily dosing (10 mg/kg i.p. injection). Plotted values = mean ± SD (n = 5). Asterisks (*) indicate statistically significant difference between virologic parameters in normal saline versus NAPs (p < 0.05) as determined by t test. Section marks (§) indicate that although not statistically significant, these values represent therapeutically relevant decreases relative to the normal saline group.