Table 2.
Summary of biochemical data obtained in PWS subjects and obese controls.
| Variables | PWS (n = 20) | Obese (n = 20) | P Value |
|---|---|---|---|
| ANGPTL8 (ng/mL) | 0.58 ± 0.21 | 0.93 ± 0.50 | 0.007 |
| Glucose OGTT0 (mg/dL) | 100.6 ± 31.6 | 90.6 ± 10.0 | 0.1 |
| Glucose OGTT120 (mg/dL) | 125.1 ± 44.9 | 142.2 ± 47.8 | 0.3 |
| Insulin OGTT0 (mIU/L) | 10.7 ± 5.0 | 13.5 ± 6.2 | 0.1 |
| Insulin OGTT120 (mIU/L) | 53.4 ± 28.1 | 106.6 ± 86.5 | 0.02 |
| C- Peptide (μg/L) | 2.3 ± 0.9 | 3.2 ± 0.9 | 0.002 |
| Matsuda | 6.39 ± 6.37 | 3.51 ± 2.25 | 0.06 |
| Stumvoll | 0.077 ± 0.029 | 0.051 ± 0.045 | 0.05 |
| HOMA-IR | 2.6 ± 1.6 | 3.0 ± 1.5 | 0.4 |
| HOMA-B | 149.4 ± 57.0 | 194.9 ± 109.3 | 0.1 |
| HbA1c (%) | 5.8 ± 1.0 | 5.7 ± 0.5 | 0.5 |
| AST (U/L) | 18.9 ± 6.7 | 29.1 ± 15.1 | 0.01 |
| ALT (U/L) | 25.0 ± 16.9 | 40.5 ± 29.9 | 0.02 |
| GGT (U/L) | 36.9 ± 50.0 | 34.0 ± 26.6 | 0.8 |
| ALP (U/L) | 77.1 ± 19.6 | 73.7 ± 14.9 | 0.5 |
| CHO (mg/dL) | 178.6 ± 42.6 | 186.9 ± 25.2 | 0.4 |
| LDL CHO (mg/dL) | 118.9 ± 39.3 | 120.4 ± 21.9 | 0.8 |
| HDL CHO (mg/dL) | 48.9 ± 11.1 | 41.1 ± 9.2 | 0.02 |
| TG (mg/dL) | 97.3 ± 35.1 | 131.6 ± 45.1 | 0.01 |
| Urate (mg/dL) | 5.4 ± 1.0 | 6.5 ± 1.1 | 0.004 |
| CRP (mg/dL) | 1.2 ± 1.3 | 1.1 ± 0.7 | 0.7 |
Data are expressed as mean ± SD. Comparison between populations was performed by ANOVA test. Significance is shown in bold characters.
OGTT, Oral Glucose Tolerance Test; OGTT0 and OGTT120, OGTT at time 0 min and 120 min; HOMA-IR, homeostatic model of insulin resistance; HOMA-B, homeostatic model of β cell function; HbA1c, glycated haemoglobin; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma glutamyl transpeptidase; ALP, alkaline phosphatase; CHO, total cholesterol; LDL CHO, low density lipoprotein cholesterol; HDL CHO, high density lipoprotein cholesterol; TG, triglycerides; CRP, C-reactive protein.