Table 2.
Univariate and multivariate analysis of cause-specific survival.
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
| P | HR | 95% | P | |
| Age ≥ 50 | 0.001 | 1.02 | 0.91–1.15 | 0.708 |
| Race | <0.001 | <0.001 | ||
| White | 1 | |||
| Black | 1.45 | 1.23–1.71 | <0.001 | |
| Other | 1.13 | 0.96–1.33 | 0.138 | |
| Married patients | 0.906 | — | — | — |
| Histologic type | <0.001 | <0.001 | ||
| Squamous cell carcinoma | 1 | |||
| Adenocarcinoma | 1.47 | 1.23–1.76 | <0.001 | |
| Adenosquamous carcinoma | 1.29 | 1.06–1.58 | 0.011 | |
| Others | 1.74 | 1.47–2.05 | <0.001 | |
| Primary site | 0.002 | 0.120 | ||
| Cervix uteri | 1 | |||
| Endocervix | 0.88 | 0.76–1.03 | 0.104 | |
| Exocervix | 0.77 | 0.54–1.09 | 0.136 | |
| Overlapping lesion of cervix uteri | 0.81 | 0.60–1.10 | 0.185 | |
| Grade | <0.001 | <0.001 | ||
| I | 1 | |||
| II | 1.89 | 1.44–2.48 | <0.001 | |
| III | 2.60 | 1.98–3.41 | <0.001 | |
| IV | 3.11 | 2.19–4.42 | <0.001 | |
| FIGO | <0.001 | <0.001 | ||
| IB | 1 | |||
| IIA | 1.83 | 1.51–2.23 | <0.001 | |
| IIB | 1.75 | 1.52–2.00 | <0.001 | |
| Node positive | <0.001 | 1.90 | 1.68–2.14 | <0.001 |
| Size | <0.001 | <0.001 | ||
| ≤2 cm | 1 | |||
| 2–4 cm | 1.93 | 1.64–2.27 | <0.001 | |
| ≥4 cm | 2.53 | 2.13–3.01 | <0.001 | |
| Surgical method | <0.001 | <0.001 | ||
| Local tumor destruction | 1 | |||
| Hysterectomy | 0.80 | 0.68–0.96 | 0.014 | |
| Pelvic exenteration | 1.45 | 1.03–2.03 | 0.033 | |
| CDS + RT | <0.001 | 1.38 | 1.20–1.59 | <0.001 |
HR = hazard ratio; CI = confidence interval; FIGO: International Federation of Gynecology and Obstetrics; CDS: cancer-directed surgery; RT: radiotherapy.