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. 2017 Jun 9;7:3207. doi: 10.1038/s41598-017-03298-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Co-evolving residue networks in the ptRNase superfamily. (a) Residue positions of the top five significant eigenmodes (ICs 1–5) are colored red, purple, blue, cyan and teal, respectively, along the primary structure of RNase A. (b) Amino acid residues of ICs 1–5, displayed using the space-filling model, mapped on the 3D structure of RNase A (PDB 7RSA). (c–e) Each panel shows the scatterplot of sequences (each circle representing a single sequence) along each IC corresponding to sequence variations of positions contributing to each IC. Stacked histograms show the distribution of sequences along each IC. Sequences are colored based on the RNase subtypes found in the entire vertebrate family (RNases 1–8 and inactive members). Sequence distributions along ICs 1 and 2, 3 and 4, 5 and 2 are shown in panels c, d, and e, respectively.