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. 2017 Jun 9;7:3145. doi: 10.1038/s41598-017-03316-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Imipramine inhibits Flavivirus replication in primary human skin fibroblasts. Human skin fibroblasts were pretreated with vehicle or imipramine at the indicated concentrations for 2 h before exposure to different Flaviviruses. Imipramine was present throughout the culture. After 48 h of culture, the presence of virus RNA in cells and infectious virus productions were quantified by RT-PCR and plaque assay, respectively. (a,d) ZIKV strain Pf13 (MOI 0.1) (b,e) WNV WT (MOI 0.1) (c,f) DENV-2 strain 16681 (MOI 0.5). The data represent mean ± SD from three independent experiments.