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. 2017 Jun 9;7:3153. doi: 10.1038/s41598-017-03368-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FPR2 promotes tumorigenesis and metastasis of GC cells in vivo. (A) Images of xenograft tumors derived from shFPR2 SGC7901 and shXN0422 and their mock cells subcutaneously injected in nude mice at indicated cell number for 5 weeks showed that FPR2-knockdown reduced the tumorigenic abilities of GC cells both in rate of tumor formation and tumor size (left panel). HE staining confirmed the GC pathological characteristics of xenograft tumors (right panel). (B) summary graphs showed the weights of tumors derived from FPR2-knockdown SGC7901 (upper) and XN0422 (lower) cells are significantly lighter than those derived from the mock cells. (C) Representative images of intraperitoneal metastasis assay showed that metastatic nodules derived from FPR2-knockdown GC cells are far less than those derived from the mock cells (left panel), and HE staining confirms the GC pathological characteristics of the metastatic nodules (right panel). (D) Histograms show the difference in number of celiac metastatic nodules derived from FPR2-knockdown GC cells and mock cells (each cell was implanted at 2 × 104 cells/mouse for 4 weeks, n = 5). *p < 0.05, ***p < 0.001.