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. 2017 Jun 9;7:3153. doi: 10.1038/s41598-017-03368-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FPR2 induces migration of GC cells mainly by activating ERK signaling pathway. (A) Hp(2–20) and Ac(2–26) (100 μM) induces chemotaxis of SGC7901 cells (left panel) and XN0422 cells (right panel), which is markedly attenuated by FPR2 knockdown and blocked by treatment with MEK1/2 inhibitor PD98059 (10 μM). (B) Western blot showed that Hp(2–20) and Ac(2–26) (100 μM) induced ERK 1/2 phosphorylation in SGC7901 cells (left panel) and XN0422 cells (right panel), while FPR2 knockdown and PD98059 treatment inhibits ERK 1/2 phosphorylation. Data are presented as mean ± SD. *p < 0.05, **p < 0.01.