Table 6.
Clinical outcomes
| Variable | EN only (n = 73) | SPN + EN (OLIMEL) (n = 52) | p value |
|---|---|---|---|
| Length of ventilation, days | 8.3 (3.8–13.3) | 6.5 (3.9–14.1) | 0.78 |
| ICU mortality | 0.51 | ||
| Yes | 13 (17.8%) | 7 (13.5%) | |
| No, patient discharged | 60 (82.2%) | 45 (86.5%) | |
| Length of stay in ICU among survivors, days | 12.6 (8.1–18.7) | 12.8 (7.9–17.8) | 0.80 |
| Hospital mortality | 0.29 | ||
| Yes | 17 (23.3%) | 8 (15.4%) | |
| No, patient discharged | 56 (76.7%) | 43 (82.7%) | |
| No, patient still in hospital at 6 months | 0 (0.0%) | 1 (1.9%) | |
| Length of stay in hospital among survivors, days | 24.0 (16.6–38.9) | 23.5 (17.5–34.7) | 0.83 |
| Time to discharge alive from hospital | 33.0 (20.2, und) | 32.5 (21.1, und) | 0.87 |
| Kaplan-Meier 6-month mortality estimatea | 27.5% | 29.5% | 0.86 |
Data reported as median (Q1–Q3) or n (%). The Mann-Whitney U test was used for continuous variables, and the chi-square test was used for categorical variables. Survival analysis was used for comparison of time to discharge alive from hospital
Abbreviations: EN enteral nutrition, ICU intensive care unit, SPN supplemental parenteral nutrition, und undefined due to <75% reaching upper quartile
aThe Kaplan-Meier estimate censors patients at the last known date alive. Altogether, 19 deaths were observed in the EN-alone arm, compared with 14 deaths in the SPN + EN arm. The median follow-up time among patients where death was not observed was 175 days in the EN-alone arm and 167 days in the SPN + PN arm