Table 4.
Univariate and multivariate analysis of predictive factors of the study cohort outcomes
| HR | Univariate (95 % CI) | p value | HR | Multivariate (95 % CI) | p value | |
|---|---|---|---|---|---|---|
| A. Catheter dislodgments | ||||||
| Age | 0.902 | [0.807–1.008] | 0.068 | 0.866 | [0.741–1.013] | 0.072 |
| Obesity | 1.718 | [0.218–3.568] | 0.608 | |||
| Renal dysfunction | 1.073 | [0.136–4.873] | 0.946 | |||
| NYHA 3 | 0.417 | [0.108–1.612] | 0.205 | |||
| QRS duration | 0.962 | [0.872–1.061] | 0.437 | |||
| LVEF | 1.072 | [0.928–1.237] | 0.345 | |||
| Quadripolar LV | 5.278 | [1.175–7.32] | 0.035* | 0.112 | [0.014–0.893] | 0.039* |
| B. Phrenic nerve stimulation | ||||||
| Age | 1.024 | [0.962–1.089] | 0.458 | |||
| Obesity | 2.604 | [0.773–8.767] | 0.122 | 0.658 | [0.144–3.01] | 0.59 |
| Renal dysfunction | 0.043 | [0.02–1.79] | 0.306 | |||
| NYHA 3 | 2.94 | [2.6–4.9] | 0.001* | 0.97 | [0.022–0.423] | 0.2 |
| QRS duration | 1.019 | [0.975–1.065] | 0.405 | |||
| LVEF | 1.012 | [0.93–1.101] | 0.79 | |||
| Quadripolar LV | 3.783 | [1.404–10.191] | 0.008* | 0.246 | [0.088–0.686] | 0.007* |
| C. Re-intervention for catheter dislodgments | ||||||
| Age | 0.902 | [0.807–1.008] | 0.068 | 0.866 | [0.741–1.013] | 0.072 |
| Obesity | 1.718 | [0.218–3.568] | ||||
| Renal dysfunction | 1.073 | [0.136–4.873] | ||||
| NYHA 3 | 0.417 | [0.108–1.612] | ||||
| QRS duration | 0.962 | [0.872–1.061] | ||||
| LVEF | 1.072 | [0.928–1.237] | ||||
| Quadripolar LV | 5.278 | [1.175–7.32] | 0.035* | 0.112 | [0.014–0.893] | 0.039* |
| D. Hospital admission for heart failure worsening | ||||||
| Age | 0.823 | [0.961–1.051] | 0.823 | |||
| Obesity | 1.062 | [0.33–3.419] | 0.92 | |||
| Renal dysfunction | 0.898 | [0.322–2.501] | 0.836 | |||
| NYHA 3 | 1.667 | [0.926–3.01] | 0.089 | 0.624 | [0.326–1.193] | 0.154 |
| QRS duration | 1.019 | [0.983–1.056] | 0.3 | 1.012 | [0.973–1.052] | 0.559 |
| LVEF | 0.98 | [0.926–1.038] | ||||
| Quadripolar LV | 1.683 | [1.04–3.03] | 0.05 | 0.516 | [0.279–0. 955] | 0.035* |
| E. Atrial fibrillation events | ||||||
| Age | 1.031 | [0.968–1.099] | 0.343 | |||
| Obesity | 5.571 | [2.038–15.232] | 0.001* | 1.36 | [1.09–1.88] | 0.02* |
| Renal dysfunction | 0.992 | [0.231–4.257] | 0.991 | |||
| NYHA 3 | 2.58 | [1.001–6.649] | 0.05* | 0.557 | [0.195–1.591] | 0.274 |
| QRS duration | 1.018 | [0.971–1.067] | 0.457 | |||
| LVEF | 1.043 | [0.95–1.146] | 0.375 | |||
| Quadripolar LV | 3.29 | [1.205–8.982] | 0.02* | 0.261 | [0.086–0.794] | 0.018* |
| F. All cause deaths | ||||||
| Age | 1.138 | [1.04–1.246] | 0.05* | 1.149 | [0.89–1.288] | 0.058 |
| Obesity | 2.5 | [0.9–2.91] | 0.986 | |||
| Renal dysfunction | 0.88 | [0.108–7.193] | 0.905 | |||
| NYHA 3 | 1.471 | [0.276–7.759] | 0.649 | |||
| QRS duration | 1.051 | [0.984–1.123] | 0.141 | |||
| LVEF | 1.069 | [0.914–1.249] | 0.404 | |||
| Quadripolar LV | 0.415 | [0.104–1.659] | 0.214 | |||
| G. Cardiac deaths | ||||||
| Age | 1.3 | [1.185–1.426] | 0.01* | 1.332 | [0.858–1.532] | 0.056 |
| Obesity | 0.7 | [0.2–2.896] | 0.168 | |||
| Renal dysfunction | 1.676 | [0.2–14.02] | 0.633 | |||
| NYHA 3 | 0.386 | [0.069–2.164] | 0.279 | |||
| QRS duration | 0.932 | [0.806–1.078] | 0.342 | |||
| LVEF | 0.912 | [0.815–1.044] | 0.201 | |||
| Quadripolar LV | 0.521 | [0.154–1.758] | 0.293 | |||
In this table the representation of study outcomes, as catheter dislodgments (A), phrenic nerve stimulation events (B), re-intervention for catheter dislodgments (C), hospital admissions for heart failure worsening (D), atrial fibrillation events (E), all cause deaths (F), and cardiac deaths (G), and multivariate predictive factors
We have used for statistical analysis, a 95% interval of confidence (IC), and a significant statistical p value, p < 0.05. The symbol * was marking factor with a p value <0.05. To test the final statistical used model, we have performed the Hosmer and Lemeshow test, with a χ² = 2.775, and a p value <0.05
NYHA 3 New York Heart Association third class, LVEF left ventricle ejection fraction, LV left ventricle