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. 2017 Jun 10;17:8. doi: 10.1186/s12895-017-0060-y

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Exposure to repeated UVB plus heat significantly decreased acetylated p53 levels in keratinocytes. Representative immunohistochemical staining of ex vivo skin either untreated, or exposed to heat, UVB or UVB plus heat, for nuclear DNA (DAPI, blue), CPD (red) and (a) phosphorylated SIRT1 (SIRT1-p), (b) caspase (casp-3), (c) total p53 or (d) acetylated p53 (p53-a382). Inset images are an enlarged view of cells positive for CPD and SIRT1 (red arrows), CPD and Casp-3 (orange arrows), CPD and p53 (green arrows) or CPD and p53-a382 (blue arrows). Broken lines denote the epidermal/dermal border. All images are at 400X magnification