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Effect of UV and/or heat exposure on p53 downstream gene targets and cell proliferation. a-b Fold change on mRNA expression of BAX, Survivin, ERCC1 or XPC in keratinocytes of the (a) skin and (b) in vitro, relative to untreated controls. c-d Bar graphs of the percentage mean (+/− SD) of keratinocytes positive for ki67 per field of view either (c) in ex vivo skin or (d) in vitro. Statistically significant differences are indicated with ** p < 0.001 and/or *** for p-values p < 0.0001
