Table 2.
Cross-phenotype gene-based genetic association tests (suggestive associations p < 0.01 bolded).
| Chr | Position start | Position end | Gene | Number of variants | AlcDep p-value | NicDep p-value | MaxDrinks p-value | CPD p-value | AlcNicDep p-value | DrinksCPD p-value |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 32259791 | 32280610 | SPOCD1 | 8 | 3.28E-03 | 7.84E-01 | 1.00E+00 | 4.44E-03 | 1.11E-01 | 7.38E-04 |
| 2 | 48873662 | 48898798 | GTF2A1L | 6 | 1.40E-02 | 8.67E-02 | 6.28E-03 | 3.37E-02 | 9.77E-04 | 9.32E-03 |
| 2 | 86433240 | 86439550 | MRPL35 | 2 | 2.12E-05 | 5.21E-02 | 4.82E-04 | 2.88E-02 | 1.42E-02 | 2.20E-03 |
| 3 | 112974641 | 113003273 | BOC | 3 | 2.39E-02 | 1.93E-02 | 2.14E-03 | 8.83E-04 | 6.27E-02 | 4.23E-04 |
| 3 | 157155314 | 157161305 | PTX3 | 3 | 3.38E-03 | 2.25E-03 | 5.92E-01 | 1.52E-01 | 3.36E-04 | 4.37E-01 |
| 5 | 37142583 | 37196028 | C5orf42 | 8 | 6.81E-03 | 3.75E-02 | 1.00E-01 | 6.52E-05 | 6.48E-02 | 1.04E-04 |
| 10 | 115959034 | 115980422 | TDRD1 | 5 | 8.16E-05 | 8.66E-03 | 4.32E-02 | 3.75E-01 | 5.67E-04 | 6.66E-01 |
| 14 | 22133648 | 22134018 | OR4E2 | 4 | 3.48E-03 | 5.96E-03 | 1.52E-02 | 7.94E-02 | 1.15E-03 | 1.41E-02 |
| 15 | 97326853 | 97327394 | SPATA8 | 3 | 4.41E-03 | 3.66E-02 | 1.00E+00 | 5.05E-03 | 3.57E-03 | 6.19E-01 |
| 17 | 12620711 | 12666691 | MYOCD | 8 | 2.02E-03 | 9.95E-02 | 2.43E-03 | 2.01E-02 | 4.11E-03 | 3.89E-04 |
| 19 | 43013363 | 43023255 | CEACAM1 | 2 | 1.00E+00 | 6.01E-01 | 3.24E-03 | 8.82E-03 | 8.39E-01 | 5.85E-03 |
| 22 | 31621792 | 31674324 | LIMK2 | 7 | 2.15E-03 | 2.46E-02 | 6.65E-01 | 8.96E-03 | 4.20E-03 | 2.43E-01 |
Note. Chr = chromosome. AlcDep = alcohol dependence diagnosis. NicDep = nicotine dependence diagnosis. MaxDrinks = maximum number of drinks consumed in a 24-hour period. CPD = cigarettes smoked per day. AlcNicDep = both alcohol and nicotine dependence diagnoses. DrinksCPD = product term of MaxDrinks and CPD.