Table 1. Associations of poor clinical evolution of CSCCs with.

A) histopathological tumor features, and B) miR-205 and mi-R203 expression. N.S. not significant. Red: significant P values. Blue: statistical trend.

			POOR PROGNOSIS CRITERIA
			Local Recurrence			Nodal Progression			Events of Poor Clinical Evolution
			YES	NO	P-value	YES	NO	P-value	YES	NO	P-value
A. Pathological Tumour Traits	Growth Pattern	Expansive	0	26	N.S.	1	15	0.064	1	25	0.066
		Mixed	1	16		1	16		2	15
		Infiltrative	3	33		8	28		9	27
	Grade of Differentiation	Good	1	24	N.S.	1	24	0.006	2	23	N.S.
		Moderate	2	35		3	34		5	32
		Poor	1	16		6	11		5	12
		YES	3	11		4	10		5	9
	Perineural Invasion				0.002			0.048			0.018
		NO	1	64		6	59		7	58
		YES	2	19		3	18		3	18
	Desmoplasia				N.S.			N.S.			N.S.
		NO	2	56		7	51		9	49
	Tumour Thickness	(Median in mm (SD))	11.5(14.5)	5.28(4.5)	0.009	6.25(5.25)	5(4.50)	0.035	8 (7.75	5 (4.58)	0.003
	Tumour Size	(Median in mm (SD))	21.5(44.5)	18(9)	N.S.	22(10.25)	18(8)	N.S.	22(10)	18(9)	0.074
B. mIRNAs expression		Expression	0	29		2	27		2	27
	miR-203				N.S.			N.S.			N.S.
		No expression	4	46		27	42		10	40
		Expression	4	35		7	32		10	29
	miR-205				0.038			N.S.			0.011
		No expression	35	40		3	37		2	38