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. 2017 Jun 12;8:681. doi: 10.3389/fimmu.2017.00681

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Copyright © 2017 Martin, Gombert, Chen, Liebens, Verleger, Kalder, Marx, Jacobs, Thiemermann and Schuerholz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of heparanase or heparan sulfate on systemic inflammatory response in C57BL/6J mice. Serum levels of interleukine-6 (IL-6), IL-10, monocyte chemoattractant protein-1 (MCP-1), C-X-C motif ligand 1, tumor necrosis factor-α (TNF-α), and IL-1β were assessed 24 h subsequent to either vehicle (sham), heparanase (1 U i.v.; Hep), or heparan sulfate (1 mg i.v.; HS) administration in 2-month-old male C57BL/6J mice. The following groups were studied: C57BL/6J vehicle (n = 8); C57BL/6J heparanase (n = 8); C57BL/6J heparan sulfate (n = 8). Data are expressed as means ± SEM for n number of observations. *p < 0.05 vs. C57BL/6J vehicle (Kruskal–Wallis test with Dunn’s multiple comparisons test).