FIGURE 6.

AZA inhibits AML tumor xenografts in athymic nude mice. (A–C) Representative photographs of harvested tumors (A) and the corresponding tumor growth curves (B) are shown. Tumor weights measured at the indicated times are shown (C). The expression levels of Jab1 and P-Akt proteins in tissues resected from the same mice were examined via Western blot analysis (D). Female nude mice bearing xenograft tumors derived from U937 were intraperitoneally injected with phosphate-buffered saline or AZA once every 3 days. At the end of the experiments, the mice were humanely killed, and the tumors were excised and weighed. The data are means with standard deviation. Compared with “control” group (student’s t-test), ^∗P < 0.05, ^∗∗P < 0.01.