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Cytotoxicity and SI of dodecyl and amphotericin B (AMB) incorporated into the NLS.
| MRC5 IC50 | SI (IC50/ | SI (IC50/ | SI (IC50/ | |
|---|---|---|---|---|
| (μg/mL) | MIC Pb18) | MIC Pb01) | MIC Pb02) | |
| Dodecyl | 17.9 | 37.3 | 37.3 | 74.7 |
| NLS+dodecyl | 17.7 | 590.0 | 590.0 | 295 |
| X increase | - | 16 | 16 | 4 |
| AMB | 0.22 | 1.8 | 1.8 | 3.7 |
MRC5 (human normal pneumocyte cells); SI (selectivity index) = (IC50/MIC), IC50 (inhibitory concentration 50%); MIC (minimum inhibitory concentration).
