Table 3.

Daily questionnaire syndrome scores.

Period	GI distressa		Epidermalb		Cephalicc		Ear–nose–throatd		Psychologicale		Emeticf
	Placebo	Ljo	Placebo	Ljo	Placebo	Ljo	Placebo	Ljo	Placebo	Ljo	Placebo	Ljo
Baseline	3.1 ± 0.5	1.6 ± 0.5	0.3 ± 0.2	0.1 ± 0.2	0.4 ± 0.1	0.5 ± 0.1	0.7 ± 0.2	0.6 ± 0.2	1.7 ± 0.6	2.6 ± 0.6	0.07 ± 0.06	0.13 ± 0.06
Week 1	2.2 ± 0.3	1.1 ± 0.3*	0.5 ± 0.2	0.01 ± 0.2	0.4 ± 0.1	0.4 ± 0.1	1.2 ± 0.4	0.7 ± 0.4	1.2 ± 0.5	2.0 ± 0.5	0.06 ± 0.03	0.02 ± 0.03
Week 2	1.7 ± 0.3	1.1 ± 0.3	0.6 ± 0.2	0.01 ± 0.2*	0.9 ± 0.2	0.2 ± 0.2**	1.3 ± 0.3	0.4 ± 0.3*	2.1 ± 0.6	1.4 ± 0.6	0.09 ± 0.06	0.01 ± 0.06
Week 3	2.0 ± 0.4	0.8 ± 0.4*	0.5 ± 0.2	0.07 ± 0.2	0.4 ± 0.1	0.3 ± 0.1	1.1 ± 0.4	0.8 ± 0.4	1.7 ± 0.4	0.9 ± 0.4	0.08 ± 0.07	0.13 ± 0.07
Week 4	2.2 ± 0.3	1.0 ± 0.3**	0.4 ± 0.2	0.07 ± 0.2	0.5 ± 0.1	0.05 ± 0.1**	1.1 ± 0.3	0.3 ± 0.3*	1.7 ± 0.6	1.6 ± 0.6	0.10 ± 0.05	0.01 ± 0.05
Week 5	1.9 ± 0.3	1.1 ± 0.3*	0.4 ± 0.2	0.03 ± 0.2	0.6 ± 0.1	0.2 ± 0.1*	1.2 ± 0.3	0.4 ± 0.3	1.9 ± 0.5	1.2 ± 0.5	0.10 ± 0.05	0.02 ± 0.05
Week 6	1.5 ± 0.2	0.9 ± 0.2	0.3 ± 0.2	0.02 ± 0.2	0.6 ± 0.1	0.02 ± 0.1**	1.0 ± 0.3	0.3 ± 0.3	1.8 ± 0.5	1.0 ± 0.5	0.08 ± 0.03	0.02 ± 0.03*
Week 7	2.0 ± 0.2	0.8 ± 0.2**	0.3 ± 0.1	0.01 ± 0.1	0.6 ± 0.1	0.04 ± 0.1***	0.8 ± 0.2	0.2 ± 0.2*	1.7 ± 0.5	1.0 ± 0.5	0.19 ± 0.07	0.01 ± 0.07
Week 8	1.6 ± 0.3	0.7 ± 0.3*	0.4 ± 0.2	0.02 ± 0.2	0.3 ± 0.1	0.04 ± 0.1*	0.5 ± 0.2	0.1 ± 0.2	1.8 ± 0.4	0.8 ± 0.4	0.04 ± 0.03	0.02 ± 0.03
Washout 1	2.1 ± 0.3	0.8 ± 0.3**	0.2 ± 0.1	0.01 ± 0.1	0.3 ± 0.1	0.03 ± 0.1	0.8 ± 0.3	0.2 ± 0.3	1.8 ± 0.4	0.8 ± 0.4	0.06 ± 0.04	0.02 ± 0.04
Washout 2	2.2 ± 0.4	0.7 ± 0.4**	0.2 ± 0.1	0.01 ± 0.1*	0.6 ± 0.1	0.04 ± 0.1***	0.6 ± 0.2	0.3 ± 0.2	1.6 ± 0.4	0.8 ± 0.4	0.11 ± 0.03	0.02 ± 0.03*
Washout 3	2.6 ± 0.5	1.0 ± 0.5*	0.3 ± 0.1	0.07 ± 0.1*	0.4 ± 0.1	0.1 ± 0.1	0.7 ± 0.2	0.4 ± 0.2	1.9 ± 0.4	1.1 ± 0.4	0.17 ± 0.06	0.06 ± 0.06
Washout 4	1.9 ± 0.4	0.7 ± 0.4*	0.3 ± 0.1	0.07 ± 0.1*	0.4 ± 0.1	0.1 ± 0.1	1.0 ± 0.3	0.4 ± 0.3	2.1 ± 0.5	1.0 ± 0.5	0.08 ± 0.05	0.08 ± 0.05

^aGastrointestinal distress syndrome includes daily symptoms of bloating, flatulence, stomach noises, and abdominal cramps.

^bEpidermal syndrome includes daily symptoms of itching, skin rash, and skin redness/flushing.

^cCephalic syndrome includes daily symptoms of headache and dizziness.

^dEar–nose–throat syndrome includes daily symptoms of sore throat, runny eyes, nasal congestion, and blocked ear canal.

^ePsychological syndrome includes daily symptoms of anxiety, depression, and stress.

^fEmetic syndrome includes daily symptoms of nausea and vomiting.

Ljo correspond to Lactobacillus johnsonii N6.2.

Data presented as least squares mean ± SEM.

*p < 0.05.

**p < 0.01.

***p < 0.