Table 1.
Summary of number of rats used in each experimental procedure.
| Experimental group | MRI | Behavior study | EEG | Spasms susceptibility |
|
|---|---|---|---|---|---|
| Single dose | Multiple doses | ||||
| Saline-exposed rats (n = 50) | |||||
| Saline injection (n = 16) | 4 | 16 | 10 | 23 | 10 (1a) |
| NMDA injection (n = 34) | |||||
| MAM-exposed rats (n = 89) | |||||
| Saline injection (n = 14) | 5 | 14 | 13 (1a) | 62 (4b) | 15 |
| NMDA injection (n = 75) | |||||
MRI, magnetic resonance imaging; EEG, electroencephalography; MAM, methylazoxymethanol acetate; NMDA, N-methyl-d-aspartate.
aIndicates the number of mortality case during the NMDA-induced spasms.
bIndicates the death associated with high dose vigabatrin and spasms.