Figure 2.

Extended-amygdala system. The 3D color model at the top depicts the location of 22 brain areas in the rat comprising the extended-amygdala system. These areas have been coalesced into a single volume (yellow) as shown in the lower 3D images for treatment groups, vehicle, idalopirdine, donepezil, and idalopirdine combined with donepezil. Areas in red are the localization of the activated voxels comprising the composite average from the rats (parentheses) in each experimental group. Once fully registered and segmented, the statistical responses for each animal are averaged on a voxel-by-voxel basis. Those averaged voxels that are significantly different from the 5 min baseline for positive BOLD in the 25–35 min post-treatment time window are show in their appropriate spatial location.