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. 2017 Mar 10;31(6):1446–1449. doi: 10.1038/leu.2017.58

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Copyright © 2017 The Author(s)

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Performance characteristics of the NGS assay. (a) Plot of the dynamic range, limit of quantification (LOQ) and limit of detection (LOD) of the method from a 10-fold dilution curve. The vertical axis represents the ratio of MRD values to curve dilution and the horizontal axis represents the logarithm value for curve dilution. R² = 0.98 and 0.96 for IGH and IGK genes, respectively, P<0.0001. (b) Progression-free survival (PFS) and overall survival (OS) plots according to MRD levels. MRD-negative values (blue) and MRD-positive values (Red). The threshold for negative values was 10⁻⁵.