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Plasmacytoid dendritic cells (pDCs) secrete IFN-α to activate the innate immune response to virus in the airway. pDCs in healthy airways secrete large amounts of IFN-α in response to viruses. The presence of Type 2 inflammation in asthmatic airways is associated with increased expression of high-affinity IgE receptor FcεRI on the surface of pDCs, which causes a blunted IFN-α response to airway viral infection.
