Table 3.
Demographics, clinical status, type of bronchiectasis, functional status, and severity of disease, according to the three study groups
| Mild Disease | Moderate Disease | Severe Disease | P Value* | |
|---|---|---|---|---|
| Total, n (%) | 394 (100) | 506 (100) | 358 (100) | |
| Demographics | ||||
| Age, yr, median (IQR) | 58 (46–66) | 71 (63–77) | 73 (65–79) | <0.001 |
| Male, n (%) | 140 (36) | 200 (40) | 166 (46) | 0.009 |
| BMI, kg/m2, median (IQR) | 25 (21–27) | 25 (22–29) | 25 (21–28) | 0.055 |
| Smokers and ex-smokers, n (%) | 129 (33) | 175 (35) | 153 (43) | 0.012 |
| Clinical status, n (%) | ||||
| Daily cough | 274 (70) | 375 (74) | 289 (81) | 0.002 |
| Daily sputum | 204 (52) | 289 (57) | 282 (79) | <0.001 |
| Hemoptysis | 57 (15) | 76 (15) | 57 (16) | 0.855 |
| Exacerbations in previous year, median (IQR) | 1 (0–2) | 2 (1–3) | 3 (2–4) | <0.001 |
| ≥3 exacerbations in previous year, n (%) | 54 (15) | 176 (36) | 206 (59) | <0.001 |
| Functional and radiological status | ||||
| FEV1 % predicted, median (IQR) | 90 (77–101) | 72 (55–90) | 49 (36–68) | <0.001 |
| FEV1 % predicted, <50%, n (%) | 8 (2.2) | 88 (19) | 174 (50) | <0.001 |
| FEV1 % predicted, <30%, n (%) | 0 (0) | 15 (3.2) | 46 (13) | <0.001 |
| LTOT, n (%) | 0 (0) | 21 (4.2) | 71 (21) | <0.001 |
| Reiff score ≥3, n (%) | 142 (40) | 292 (63) | 259 (81) | <0.001 |
| Microbiology | ||||
| Colonized patients | 75 (19) | 178 (35) | 232 (65) | <0.001 |
| Pseudomonas aeruginosa | 3 (0.8) | 42 (8.3) | 144 (40) | <0.001 |
| Other pathogens | 72 (18) | 136 (27) | 88 (25) | 0.009 |
Definition of abbreviations: BMI = body mass index; BSI = Bronchiectasis Severity Index; IQR = 25th–75th interquartile range; LTOT = long-term oxygen therapy.
*
Mild vs. moderate vs. severe disease: mild = BSI score 0–4; moderate = BSI score 5–8; severe = BSI score ≥9.