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. 2017 Jun 10;26(17):966–985. doi: 10.1089/ars.2016.6630

FIG. 6.

FIG. 6.

GC1 is indispensable for normal skeletal muscle fatigue resistance. The isometric tetanic contractile properties of TA muscles in male and female WT and GC1−/− mice in situ. n = 9 for male groups, n = 10 and 7 for female WT and GC1−/− groups, respectively. (A) Maximal tetanic isometric force output. (B) Specific force output. n = 19 for WT and 16 for GC1−/− groups. (C) Normalized force–stimulation frequency relationship in WT and GC1−/− TA muscles. n = 18 per group. (D) Contraction-induced fatigue resistance. n = 39 and 34 for WT and GC1−/− groups, respectively. (E) Fiber composition in TA muscles from male and female WT and GC1−/− mice. n = 7 and 6 for male and female groups, respectively. Isometric twitch contractile properties of TA muscles from WT and GC1−/− male and female mice. (F) Maximum isometric twitch force output, (G) specific isometric twitch force output, (H) time to maximum isometric twitch force, and (I) time taken for muscle force to return to half maximum twitch force (½ relaxation time) in WT and GC1−/− TA muscles. For (F–I), n = 9 male WT groups. n = 10 and 7 for female WT and GC1−/− groups, respectively. (A, D, E) *p < 0.05; **p < 0.01; and ***p < 0.001 from regular two-way ANOVA using sex and genotype (A, E) or genotype and time (D) or as variables with Tukey's multiple comparison test.