Table 3.
Current available commercial tissue-engineered therapies for wound healing
| Commerical Products | Product Composition |
|---|---|
| Acellular products | |
| Biological matrix | |
| Promogram™ (Acelity L.P., Inc.) | Oxidized regenerated cellulose and collagen |
| Puraply® (Organogenesis, Inc.) | Porcine-derived type I collagen |
| MatriDerm® (MedSkin Solutions Dr. Suwelack AG) | Bovine collagen fibrils with elastin |
| Tisseel® (Baxter International, Inc.) | Fibrin |
| Beriplast P (CSL Behring) | Freeze-dried fibrinogen-factor XIII and thrombin |
| EVICEL® (Ethicon) | Fibrin |
| Hyaff® (ATGmed–AT Technologies GmbH) | Hyaluronic acid |
| Hycoat® (The Hymed Group) | Sodium hyaluronate |
| Synthetic/biosynthetic matrix | |
| Integra® (Integra Life Sciences Corp.) | Bilayer matrix bovine collagen and silicon |
| Hyalomatrix® (Anika Therapeutics) | Silicon membrane bound to hyaluronic acid |
| Biobrane® (Mylan and Smith & Nephew) | Silicon membrane bound to porcine collagen-coated nylon mesh |
| Suprathel® (Polymedics Innovation) | D.Lactide trimethylene carbonate and epsilon-capronolactone membrane |
| Terudermis (Olympus Terumo Biomaterial Corp.) | Bovine dermal cross-linked atelocollagen with or without silicone |
| Pelnac (Gunze Ltd., Medical Materials Centre) | Procine tendon-derived atelocollagen type I with or without silicone film |
| Biologically processed matrix | |
| OASIS Wound Matrix® (Cook Biotech, Inc.) | Acellular procine small intestinal submucosa |
| PriMatrix® (Integra Life Science Corp.) | Acellular fetal bovine dermis |
| MatriStem® (ACell, Inc.) | Acellular porcine urinary bladder |
| SurgiMend® (Integra Life Science Corp.) | Acellular fetal or neonatal bovine dermis |
| AlloDerm® (LifeCell Corp.) | Acellular human dermis |
| GraftJacket® (Wright Medical Technology, Inc.) | Acellular human dermis |
| DermaMatrix® (Musculoskeletal Transplant Foundation and Synthes CMF) | Acellular human dermis |
| EZ Derm® (Mölnlycke Healthcare, LLC) | Acellular silver-impregnated aldehyde cross-linked porcine dermis |
| Amnioexcel (Derma Sciences, Inc.) | Dehydrated amnion-derived tissue |
| Biovance® (Alliqua BioMedical, Inc.) | Dehydrated amnion-derived tissue |
| Grafix® (Osiris Therapeutics, Inc.) | Cryopreserved amnion-derived tissue |
| Epifix®/EpiBurn® (MiMedx Group, Inc.) | Dehydrated and sterilized human amnion/chorion tissue |
| Cellular products | |
| Epidermal products | |
| Epicel® (Genzyme Tissue Repair Corporation) | Cultured autologous keratinocytes |
| Keratinozyten Sheets (DIZG) | Cultured autologous keratinocytes |
| ReCell® (Avita Medical) | Autologous epidermal cells in liquid suspension |
| MySkin (Celltran Ltd.) | Cultured autologous keratinocytes on membrane |
| Laserskin®/Vivoderm® (Fidia Advanced Biopolymers) | Cultured autologous keratinocytes in laser-perforated hyaluronic acid |
| Dermal/epidermal-dermal (composite) products | |
| Theraskin (Soluble Systems LLC) | Human allogeneic split-skin graft, including keratinocytes and fibroblasts |
| Dermagraft® (Organogenesis, Inc.) | Neonatal foreskin-derived fibroblast seeded in polyglycolic acid or polyglactin-910 mesh |
| Apligraf® (Organogenesis, Inc.) | Bilayered human neonatal epidermal keratinocytes and neonatal foreskin-derived fibroblast seeded in bovine collagen matrix |
| StrataGraft® (Stratatech Corp.) | Bilayered human dermal fibroblast and human keratinocyte-derived fully stratified epidermis |
| Growth factor products | |
| Regranex® (Ortho-McNeil) | Human recombinant platelet-derived growth factor |
| Autologel® (Cytomedix, Inc.) | Platelet-rich plasma |