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. 2017 Jun 1;27(3):121–129. doi: 10.1089/nat.2016.0650

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© Stanley T. Crooke et al. 2017; Published by Mary Ann Liebert, Inc.

This article is available under the Creative Commons License CC-BY-NC (http://creativecommons.org/licenses/by-nc/4.0). This license permits non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. Permission only needs to be obtained for commercial use and can be done via RightsLink.

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FIG. 1. — Platelet levels over time in subjects with rheumatoid arthritis treated with ISIS 104838, which targets TNFα, in a 12-week, randomized, placebo-controlled phase 2 trial. Top panel shows the percent change from baseline and the bottom panel shows the absolute platelet count over time. Data lines represent dose group: − placebo, ··· 100 mg/week, − − 200 mg/week, and −·− 400 mg/week. Symbols represent individual subject data. Vertical gray lines indicate the first and last dose of the 12-week treatment period.