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. 2017 Jun 6;8:15180. doi: 10.1038/ncomms15180

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) The first panel shows the number of MSI events across 708 whole genomes, stratified by the length of the repeat unit. The second and third panels report the MSI status and the total count of SNVs, respectively. The fourth panel shows the distribution of MSI events across the genome. (b) Landscape of MSI in mitochondrial DNA across 308 COAD, STAD and UCEC low-pass whole genomes. MSI events, including frameshift and in-frame mutations, are shown in black.