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. 2017 May 8;8(6):622–627. doi: 10.1021/acsmedchemlett.7b00037

Table 1. Percentage Yields of Alkylation of Model Nucleophiles by QMPs.

  nucleophile (%)
QMP 4-methylbenzenethiol piperidinea benzyl alcohol
1 84 80 0
2 87 77 8
3 83 81 11
4 83 79 13
1-HCl 83 78 8
2-HCl 83 78 12
3-HCl 85 81 10
4-HCl 84 69 16
a

Compounds 3 and 3-HCl were reacted with pyrrolidine because of their piperidinyl groups in the existing structure.