Table 3. Activity, Solubility, Cytotoxicity and Acute Toxicity of Selected Compounds.

	MIC (μM)
compd.	MDR-MTB 12525	MDR-MTB 14231	water solubilitya (mg/mL)	CC50b Vero cells (μM)	acute toxicityc
11l	0.092	0.086	1.17	1677.85	5/5
11m	<0.035	<0.035	1.24	145.35	5/5
11n	<0.035	<0.035	1.13	1398.13	5/5
11o	<0.035	<0.035	0.67	1169.75	5/5
12b	0.080	0.060	2.04	266.34	5/5
12c	<0.035	<0.035	1.56	289.26	3/5
12e	0.056	0.095	1.40	86.20	NT
12f	<0.035	0.034	1.12	810.61	4/5
13d	0.119	0.123	1.20	78.86	NT
PBTZ-169	<0.035	<0.035	0.90	1402.82	NT
INH	>291.7	34.48
RFP	27.24	>48.60

^aThe water solubility was tested in 0.01 M HCl solution (approximate pH 2.0).

^bThe 50% cytotoxic concentration.

^cNo. of animals that survived/total no. of animals; NT, not tested.