Table 4. PK Profiles of 11k–n and 12b, 12e Dosed Orally in Mice at 50 mg/kg (n = 3)^a.

compd.	T1/2 (h)	Tmax (h)	Cmax (ng/mL)	AUC0-inf (h·ng/mL)	MRT (h)
11l	10.66 ± 5.62*	1.00 ± 0	1682 ± 307	24619 ± 3478**	15.9 ± 8.66*
11m	3.59 ± 0.64	1.33 ± 0.58	2700 ± 933*	28716 ± 9878*	6.07 ± 0.35**
11n	3.53 ± 1.63	0.67 ± 0.29	901 ± 110	4871 ± 935	4.83 ± 0.66
11o	4.68 ± 0.92*	0.50 ± 0	426 ± 243*	2599 ± 1220	5.80 ± 0.84*
12b	3.46 ± 3.23	0.67 ± 0.29	17.6 ± 5.41**	41.8 ± 33.0**	5.20 ± 4.50
12f	3.11 ± 0.35	1.08 ± 0.88	1234 ± 159	6024 ± 379	4.00 ± 0.85
PBTZ169	2.87 ± 1.03	0.83 ± 0.29	1300 ± 422	5478 ± 1730	3.73 ± 0.94

^aNote: noncompartmental calculations gave these parameter estimates. *P < 0.05. **P < 0.01, one-tail t test compared with PBTZ169.