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. Author manuscript; available in PMC: 2017 Jun 12.
Published in final edited form as: Nat Med. 2017 Jan 16;23(2):185–191. doi: 10.1038/nm.4268

Figure 4. Temporal evolution of escape from 10-1074 over time in subjects 1HB1, 1HB3, 1HC1, 1HD1, 1HD6K, and 1HD10K.

Figure 4

Plots display relative frequencies of escape mutations observed in SGS data at envelope positions 325, 332 and 334 as shaded areas over time. Sequencing was performed on day 0 (all subjects), and at week 1 (1HB3, 1HD1), week 2 (1HB3), week 4 (all subjects), week 8 (1HD6K, 1HD10K), week 12 (1HD6K, 1HD10K), week 16 (1HB3), week 20 (1HD6K) and week 24 (1HB1, 1HC1, 1HD1) (see Supplementary Table 5 for absolute numbers). White line indicates serum concentration of 10-1074 as determined by TZM.bl assay (Supplementary Table 3). White circles without border depict 10-1074 serum levels below the limit of detection.