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. 2017 Jun 12;36:78. doi: 10.1186/s13046-017-0548-7

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — ANGPTL1 inhibits liver metastasis in CRC and prolongs OS in vivo. a Histological examination of liver sections from SW620-ANGPTL1 and SW620-Ctrl groups. Liver lesions (black arrow) were confirmed as liver metastasis of CRC. b In the hemi-spleen liver metastasis model, the SW620-ANGPTL1 group had lower incidence of liver metastasis (red circle) and lower radiance intensity of liver lesions than the SW620-Ctrl group, which was illustrated by the in vivo imaging system. In addition, the rate of extrahepatic metastasis (black circle) was also lower in SW620-ANGPTL1 cells. c The mice in the SW620-ANGPTL1 group had longer OS (P = 0.02)