Table 1.
Biochemical characteristics of study subjects.
| Normal weight (n = 18) |
Obesity (n = 34) |
Obesity + HS (n = 42) |
|
|---|---|---|---|
| Gender (female/male) | 8/10 | 17/17 | 16/26 |
| Age (years) | 14 (12.75–15) | 12 (11–13)a | 13.5 (12–15)b |
| BMI (kg/m2) | 20 (19–20.6) | 26.8 (25.1–30.8)a | 30.1 (27.5–36.1)b,c |
| AST (U/L) | 31 (27–38.5) | 39 (29.5–47.5) | 37.5 (25–56) |
| ALT (U/L) | 19 (16–22.5) | 31 (21.5–45.5)a | 54.5 (33.5–79.5)b,c |
| Ratio (AST/ALT) | 1.7 (1.4–1.8) | 1.3 (1–1.5)a | 0.7 (0.6–0.8)b,c |
| Triglycerides (mg/dL) | 82 (62.8–98.3) | 114 (103.5–218)a | 135.5 (92–179.3)b |
| Cholesterol (mg/dL) | 151.5 (133.5–171) | 159 (145.5–187.5) | 161 (144.8–185.3) |
| HDL (mg/dL) | 54.5 (48–60) | 46 (41–51.5)a | 47.5 (38–54) |
| VLDL (mg/dL) | 16 (12.5–19.5) | 23 (21–44)a | 29 (18–36)b |
| Fating glucose (mg/dL) | 84 (78–86) | 87 (81–93.5) | 87.5 (82.75–93)b |
| Fasting insulin (μU/mL) | 9.6 (7.5–14.7) | 18.4 (15.7–22.2)a | 19 (14.9–25.1)b |
| HOMA-IR | 2.03 (1.6–2.9) | 4.11 (3.2–4.8)a | 4.12 (3.2–5.4)b |
Data are presented as median (percentile 25–percentile 75). Comparison between groups was made with a Mann–Whitney U test. aSignificant difference (P < 0.05) between obesity and normal weight group; bbetween obesity + HS and normal weight group; cbetween obesity + HS and obesity group. HOMA-IR: Homeostasis Model Assessment for Insulin Resistance.