Table 1.
Patient characteristics and summary of CNAs and somatic mutations.
| ALL | wt 17p | del(17p) | p-value | |
|---|---|---|---|---|
| n | 277 (100%) | 208 (75%) | 69 (25%) | |
| Male | 163 (59%) | 118 (57%) | 45 (65%) | 0.26 |
| Age of onset | 55 (32 - 86) | 54 (32 - 78) | 61 (38 - 86) | 2.2e-05 |
| Treated before sampling | 74(27%) | 39(19%) | 35(51%) | 6.4e-07 |
| IGHV mutated | 135(52%) | 125(64%) | 10(16%) | 1.2e-11 |
| Complex karyotype | 42(32%) | 20(21%) | 22(61%) | 4.03e-05 |
| FISH cytogenetics | ||||
| 13q14 loss | 170(61%) | 139(67%) | 31(45%) | 1.9E-4 |
| 11q loss | 37(13%) | 29(14%) | 8(12%) | 0.55 |
| Trisomy 12 | 36(13%) | 25(12%) | 11(16%) | 0.54 |
| Profiled by WESa | 176 (100%) | 123 (70%) | 53 (30%) | |
| Total mutations | 19 (0 - 94) | 18 (0 - 94) | 21 (7 - 68) | 0.0048 |
| Nonsynonymous mutations | 14 (0 - 70) | 13 (0 - 70) | 16 (5 - 54) | 0.0055 |
| Synonymous mutations | 4 (0 - 24) | 4 (0 - 24) | 4 (1 - 14) | 0.14 |
| Subclonal mutations | 9 (0 - 89) | 9 (0 - 89) | 8 (2 - 35) | 0.9 |
| Clonal mutations | 9 (0 - 34) | 7 (0 - 24) | 12 (0 - 34) | 5.8E-4 |
| Profiled by SNPa | 200 (100%) | 145 (72%) | 55 (28%) | |
| # of CNAs | 1 (0 - 36) | 1 (0 - 16) | 7(0 - 36) | 1.5e-16 |
| # of losses | 1 (0 - 35) | 1 (0 - 16) | 6 (0 - 35) | 5e-15 |
| # of gains | 0 (0 - 19) | 0 (0 - 3) | 1 (0 - 19) | 3.3e-08 |
| Lost Mb | 3 (0 - 530) | 1.2(0 - 88) | 97 (0 - 530) | 2.9e-18 |
| Gained Mb | 0 (0 - 340) | 0 (0 - 260) | 5.9 (0 - 340) | 9.9e-6 |
| 8p loss | 21(10%) | 6(4%) | 15(27%) | 1.1e-05 |
| 3p loss | 15(8%) | 0(0%) | 15(27%) | 8.1e-10 |
| 4p loss | 14(7%) | 2(1%) | 12(22%) | 4.1e-06 |
| 9p loss | 15(8%) | 2(1%) | 13(24%) | 1.1e-06 |
| Loss in 3p, 4p, or 9p | 31(16%) | 3(2%) | 28(51%) | 8.6e-16 |
a
Median values and ranges are presented for the WES and SNP analysis.