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. Author manuscript; available in PMC: 2017 Jun 12.
Published in final edited form as: Am J Clin Pathol. 2010 Jan;133(1):92–100. doi: 10.1309/AJCP7W9VMJENZOVG

Image 2.

Image 2

A, 3qG presenting as part of a derivative chromosome. Left panel, G-banding demonstrates additional material added to the short arm of chromosome 16. Right panel, Fluorescence in situ hybridization (FISH) with a whole chromosome 3 paint probe shows hybridization to the 2 normal No. 3 chromosomes and to the short arm of the abnormal chromosome 16. The abnormal chromosome 16 is designated as der(16)t(3;16)(q25;p13.3). B, G-banding, M-FISH, and array comparative genomic hybridization (CGH) resolve a complex karyotype with 3qG. Left panel, G-banding reveals gain of 2 extra copies of chromosome 1q resulting from a supernumerary t(1;1), an abnormal chromosome 18 with material of unknown origin added to its distal long arm, and a small supernumerary chromosome. Middle panel, Multicolor FISH confirms the gain of chromosome 1q material and further shows that the material added to chromosome 18 is derived from chromosome 9, and the small supernumerary chromosome is derived from chromosome 3. Right panel, CGH reveals the region of 3q in the marker extends frp, 3q21 to the 3q telomere (2 extra copies of this region are present).