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Deficiency of SIRT1 partially attenuates USP22‐induced activation of the AKT/MRP1 pathway in BEL7402 cells. (A) AKT/MRP1 pathway expression was monitored by western blot analysis in BEL7402 cells with USP22 overexpression and/or SIRT1 knockdown by shRNA. Values are represented as the means under the bands. (B) Co‐immunoprecipitation assays were used to verify the interaction between USP22 and SIRT1.
