Table 2.

Additional dysregulated lncRNAs in breast cancer identified through recent transcriptomic screens

lncRNAs	Notes
LINC00657, LINC00346, LINC00654, HCG11	High expression of all four predicted poorer overall survival. Knockdown of LINC00657 decreased proliferation.
LINC00705, LINC00310, LINC00704, LINC00574, FAM74A3, UMODL1-AS1, ARRDC1-AS1, HAR1A, LINC00323	High expression of all nine associated with poor disease free survival.
HOTAIRM1, LINC00340	Enriched in basal breast tumors.
HOTAIR	Enriched in HER2 subtype
TOPORS-AS1, RP11-35G9.3	High expression is associated with good patient outcome
BCAL8	Enhances proliferation, anchorage-independent growth, and tumor growth in nude mice.
CTD-2015G9.2, CTD2527121.15, LINC00393, LINC001198, RP11-10A14.5, RP11-19E11.1	Enriched in basal-like breast cancer.
LINC01297 RP11-303E16.2	In ER+ tumors, LINC01297 is highly expressed and RP11-303E16.2 is downregulated. Together their expression can divide patients into ER+ and ER-.
CYTOR	Correlates with poor survival and is critical for proliferation and migration
HIF1A-AS2, AK124454	Part of an mRNA-lncRNA signature that predicts recurrence-free survival and pathologic complete remission after taxane-based neoadjuvant chemotherapy. Both lncRNAs promote proliferation, invasion, and paclitaxel resistance.
BRCAT49	Breast cancer and lineage-associated lncRNA located near a SNP associated to breast cancer in several GWASs.
DCCAM-AS1	Highly expressed in breast cancer tissues. Strongly induced by estrogen. Enhances proliferation, invasion, anchorage-independent growth of cell lines and xenograft growth and metastasis in mice.
lncRNA152, lncRNA67	Estrogen regulated lncRNAs that are overexpressed in breast cancer tumors. Both are necessary and sufficient for proliferation of certain breast cancer cell lines.
LIMT	Prevents migration, invasion, and metastasis. Depleted in basal-like and HER2 positive tumors. Loss of LIMT is correlated with a decrease in survival.