Table 6.

Weighted/adjusted diagnostic accuracy of two simple confirmatory assays

	Guinea, Conakry	Uganda, Kitgum	Uganda, Arua	Kenya, Homa Bay	Cameroun, Douala	DRC, Baraka	Total
ImmunoComb II HIV 1&2 CombFirm – interpretation according to manufacturer
Sensitivity; 95% CI	100; 98.3–100	100; 98.3–100	100; 98.3–100	100; 98.3–100	100; 98.3–100	100; 98.3–100	100; 99.7–100
Specificity; 95% CI	99.7; 98.6–99.9	98.3; 94.9–99.5	97.7; 94.1–99.1	100; 98.4–100	99.1; 96.6–99.7	98.5; 95.8–99.5	98.8; 98.0–99.3
PPV; 95% CI	99.2; 96.7–99.8	89.4; 72.8–96.4	90.1; 77.6–96.0	100; 98.4–100	98.2; 94.1–99.5	88.3; 71.5–95.7	96.5; 94.3–97.9
NPV; 95% CI	100; 98.3–100	100; 98.3–100	100; 98.3–100	100; 98.4–100	100; 98.3–100	100; 98.2–100	100; 99.7–100
ImmunoComb II HIV 1&2 CombFirm – alternative interpretation
Sensitivity; 95% CI	100; 98.3–100	100; 98.3–100	100; 98.3–100	100; 98.4–100	100; 98.3–100	100; 98.3–100	100; 99.7–100
Specificity; 95% CI	99.7; 98.6–99.9	98.3; 94.9–99.5	99.3; 96.4–99.9	100; 98.4–100	100; 98.3–100	99.9; 99.7–100	99.5; 98.9–99.8
PPV; 95% CI	99.2; 96.7–99.8	89.2; 72.5–96.3	97.0; 85.1–99.5	100; 98.4–100	100; 98.3–100	99.6; 97.0–100	98.5; 96.7–99.4
NPV; 95% CI	100; 98.3–100	100; 98.3–100	100; 98.3–100	100; 98.4–100	100; 98.3–100	100; 98.2–100	100; 99.7–100
Geenius HIV 1/2 confirmatory assay – automated reading
Sensitivity; 95% CI	100; 98.3–100	96.2; 77.8–99.5	100; 98.3–100	100; 98.4–100	100; 98.3–100	100; 98.3–100	99.7; 97.8–100
Specificity; 95% CI	98.4; 95.0–99.5	98.3; 94.8–99.5	97.0; 93.0–98.7	100; 98.4–100	98.9; 96.9–99.6	98.4; 95.8–99.4	98.4; 97.5–99.0
PPV; 95% CI	96.5; 89.4–98.9	89.4; 72.8–96.4	88.0; 75.4–94.6	100; 98.4–100	97.7; 93.7–99.2	86.9; 71.5–94.6	95.5; 93.0–97.1
NPV; 95% CI	100; 98.1–100	99.4; 96.0–99.9	100; 97.8–100	100; 98.4–100	100; 98.4–100	100; 98.2–100	99.9; 99.3–100
Geenius HIV 1/2 confirmatory assay – visual reading
Sensitivity; 95% CI	100; 98.3–100	96.2; 77.8–99.5	100; 98.3–100	100; 98.4–100	100; 98.3–100	100; 98.3–100	99.7; 97.8–100
Specificity; 95% CI	98.2; 95.0–99.4	97.8; 94.2–99.2	94.7; 90.2–97.2	100; 98.4–100	98.9; 96.8–99.6	98.3; 95.7–99.4	97.9; 96.9–98.6
PPV; 95% CI	96.1; 89.3–98.6	86.3; 70.0–94.5	80.4; 67.9–88.9	100; 98.4–100	97.7; 93.7–99.2	86.9; 71.4–94.6	94.1; 91.4–96.0
NPV; 95% CI	100; 98.1–100	99.4; 96.0–99.9	99.8; 99.2–100	100; 98.4–100	100; 98.4–100	100; 98.1–100	99.9; 99.3–100

PPV = positive predictive value, NPV = negative predictive value.