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| Option | Method | Description |
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| A | PHIVE/hiPHIVE | Performs phenotype comparisons with human, mouse and fish genes and their neighbors in the interactome (hiPHIVE) or only to mouse (PHIVE) |
| B | PhenIX | Performs phenotype comparisons with existing clinical data |
| C | ExomeWalker | Allows network analysis against previously implicated genes |
| D | No phenotype prioritization | Runs Exomiser without phenotype prioritization |
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