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. 2017 May 16;51(1):49–62. doi: 10.3892/ijo.2017.4001

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Copyright: © Kojima et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Identification of cell subsets based on p75NTR expression and cell cycle status in surgically resected ESCC specimens. (A) Representative results of positive staining for h&E, p75NTR and Ki-67 in a serial section of a well differentiated ESCC specimen. Original magnification, ×200; scale bar, 200 µm. (B) Correlation between p75NTR expression and overall survival after surgery. In all, 95 patients with ESCC were analyzed by performing Kaplan-Meier survival analysis (log-rank test). (C) Representative results of double immunohistochemical staining of p75NTR (red) and Ki-67 (brown) in a well differentiated tumor specimen (upper left panel) and a poorly differentiated tumor specimen (lower left panel). Nuclei were stained with hematoxylin. The white, red, blue and green arrowheads indicate p75NTR-positive/Ki-67-negative, p75NTR-positive/Ki-67-positive, p75NTR-negative/Ki-67-negative and p75NTR-negative/Ki-67-positive cells, respectively; scale bar, 200 µm. The number of cells of each subset was counted (right panels). The error bars represent standard error of mean. (D) Correlation between the proportion of p75NTR-positive/Ki-67-negative cells in tumors and overall survival after curative surgery. In all, 20 patients with p75NTR-positive ESCC tumors were analyzed by performing Kaplan-Meier survival analysis (log-rank test).

Identification of cell subsets based on p75NTR expression and cell cycle status in surgically resected ESCC specimens. (A) Representative results of positive staining for h&E, p75NTR and Ki-67 in a serial section of a well differentiated ESCC specimen. Original magnification, ×200; scale bar, 200 µm. (B) Correlation between p75NTR expression and overall survival after surgery. In all, 95 patients with ESCC were analyzed by performing Kaplan-Meier survival analysis (log-rank test). (C) Representative results of double immunohistochemical staining of p75NTR (red) and Ki-67 (brown) in a well differentiated tumor specimen (upper left panel) and a poorly differentiated tumor specimen (lower left panel). Nuclei were stained with hematoxylin. The white, red, blue and green arrowheads indicate p75NTR-positive/Ki-67-negative, p75NTR-positive/Ki-67-positive, p75NTR-negative/Ki-67-negative and p75NTR-negative/Ki-67-positive cells, respectively; scale bar, 200 µm. The number of cells of each subset was counted (right panels). The error bars represent standard error of mean. (D) Correlation between the proportion of p75NTR-positive/Ki-67-negative cells in tumors and overall survival after curative surgery. In all, 20 patients with p75NTR-positive ESCC tumors were analyzed by performing Kaplan-Meier survival analysis (log-rank test).