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. 2017 May 24;51(1):169–183. doi: 10.3892/ijo.2017.4018

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Copyright: © Jiang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of Fyn and hnRNP E1 on the invasion and metastasis of pancreatic cancer cells. (A–C) Transwell and wound-healing assays revealed that the activity of Fyn and/or the expression of hnRNP E1 significantly affected the invasion and migration abilities of BxPC3 pancreatic cancer cells in vitro. (D–F) An assay of the subcutaneous tumor mass and liver metastatic nodules revealed that the activity of Fyn and/or the expression of hnRNP E1 significantly affected the tumorigenesis and metastasis of BxPC3 pancreatic cancer cells in vivo. Each group of xenograft experiments included 5 mice. ^*P<0.05. Data are presented as the mean ± standard deviation from ≥3 independent experiments.