Figure 7.

Genes associated to tumorigenesis and/or cancer progression found differentially methylated in HA22T/VGH sorafenib treated cells. The genes are grouped based on their role: apoptosis (A), invasion (B) and angiogenesis (C) as well as genes belonging to several signaling pathways such as JAK-STAT (D), RAF/MEK/ERK (E), PI3K/AKT (F), JNK (G) and NF-κB (H). Generally, we found a trend where oncogenes were hypermethylated and TSG were hypometh-ylated after sorafenib treatment. In light blue and red are reported genes found hypomethylated or hypermethylated, respectively. Genes known to be TSG are underlined while genes known to be oncogenes are not underlined. Green and red lines indicate the activation or inhibition of a gene product or a signaling pathway, respectively.