Table I.

Distribution of the 1,280 DMR based on CpG density.

DMR	Observed to expected CpG ratio (Obs/Exp CpG)a	No. of DMR	Hypermethylated DMR (%)	Hypomethylated DMR (%)
Total DMR	Obs/Exp CpG ≥60%	292	2.7	97.3
	60% < Obs/Exp CpG <30%	364	55.5	44.5
	Obs/Exp CpG ≤30%	624	76.3	23.7
DMR in promoter region	Obs/Exp CpG ≥60%	215	1.9	98.1
	60% < Obs/Exp CpG <30%	114	50.9	49.1
	Obs/Exp CpG ≤30%	194	77.8	22.2
DMR in gene body	Obs/Exp CpG ≥60%	60	6.7	93.3
	60% < Obs/Exp CpG <30%	223	58.7	41.3
	Obs/Exp CpG ≤30%	377	75.3	24.7
DMR in CDS end of the gene	Obs/Exp CpG ≥60%	17	0	100
	60% < Obs/Exp CpG <30%	27	48.1	51.9
	Obs/Exp CpG ≤30%	53	77.4	22.6

^aObserved to expected CpG ratio = number of CpG x (DMR length) / (number of C x number of G).