Table IV.
Molecular signaling pathways found enriched by WebGestalt tool.
| Category | Molecular signaling pathway | Genes count | Raw P-value | Adjusted P-value | Genes |
|---|---|---|---|---|---|
| Wikipathway | Insulin signaling pathway | 20 | 4.65E-08 | 6.88E-06 | FOS, FOXO3, GRB10, HRAS, MAP2K2, MAP2K7, MAP3K14, MAP3K8, MAPK3, MAPK8, MINK1, PIK3CA, PRKAA2, PRKCZ, RAC1, RPS6KA4, SHC1, SHC2, TRIB3, TSC2 |
| Wikipathway | Kit receptor signaling pathway | 12 | 3.16E-07 | 1.65E-05 | FOS, FOXO3, GRB10, HRAS, MAP2K2, MAPK3, MAPK8, SHC1, STAT3, STAT5A, STAT5B |
| Wikipathway | Prolactin signaling pathway | 14 | 3.35E-07 | 1.65E-05 | FOS, HRAS, JAK1, MAP2K2, MAPK3, MAPK8, PIK3CA, RAC1, SHC1, STAT3, STAT5A, STAT5B, TEC, ZAP70 |
| Wikipathway | AGE-RAGE pathway | 12 | 1.53E-06 | 5.66E-05 | ATF2, LGALS3, MAPK3, MAPK8, MMP7, PRKCZ, RAC1, SHC1, SMAD2, STAT3, STAT5A, STAT5B |
| Wikipathway | IL-2 signaling pathway | 10 | 2.13E-06 | 6.29E-05 | FOS, FOXO3, HRAS, JAK1, MAP2K2, MAPK3, SHC1, STAT3, STAT5A, STAT5B |
| Wikipathway | IL-3 signaling pathway | 10 | 2.55E-06 | 6.29E-05 | FOS, HRAS, JAK1, MAPK3, MAPK8, PRKACA, SHC1, STAT3, STAT5A, STAT5B |
| Wikipathway | MAPK signaling pathway | 17 | 5.33E-06 | 0.0001 | ATF2, DAXX, FOS, HSPA1B, IKBKG, IL1R1, MAP2K2, MAP2K7, MAP3K14, MAP3K8, MAPK3, MAPK8, MINK1, PRKACA, PRKCZ, RAC1, STK3 |
| Wikipathway | IL-5 signaling pathway | 9 | 6.07E-06 | 0.0001 | FOXO3, FOS, JAK1, MAP2K2, MAPK3, SHC1, STAT3, STAT5A, STAT5B |
| Wikipathway | AMPK signaling pathway | 10 | 1.65E-05 | 0.0002 | TSC2, CAB39, CDKN1A, CPT1A, FASN, PFKFB3, PIK3CA, PLCB1, PRKAA2, PRKACG |
| Wikipathway | TCR signaling pathway | 13 | 1.03E-05 | 0.0002 | ATF2, FOS, HRAS, IKBKG, IRF4, MALT1, MAP2K2, MAP3K14, MAP3K8, MAPK3, MAPK8, SHC1, ZAP70 |