Fig 2. Computer model results.

(A) Temperature (left half of figure) and perfusion map (right half of figure) at the end of a 12 min ablation. This perfusion map varied during heating depending on thermal dose (see supporting information, S1 File) (B) Temperature at the end of a 12 min ablation (left half of figure), and total tissue doxorubicin concentration 30 min after completion of ablation (right half of figure). The RF heating electrode is located at the center (gray: insulated catheter region; white: active tip region). The dashed line indicates the location where concentration profile is plotted in Fig 4, and also indicates approximate slice location of in vivo tissue slices in Fig 3.