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Computer simulation results: (A) Systemic plasma concentration of TSL-Dox (i.e. encapsulated Dox). Areas under the curve (AUC’s) are colored/shaded for an ablation heating cycle initiated immediately following a 30 min TSL-Dox infusion (5, 12, and 30 min duration), or following 1 and 2 hours after infusion (12 min duration). (B) Systemic plasma AUC of TSL-Dox correlates with total amount of doxorubicin delivered to the target tissue (R2 = 0.97).
