Table I.
Fifty Genes With Most Significant P-Values From the 323 Probes (From a Total of 23,383 Probes Analyzed) and an Expression 1.5-Fold Change Between the Seven Prader–Willi Syndrome Males and the Three Comparison Males (Ranked by Fold Change)
| Gene | Fold change | P-value | Genbank acc. | Chromosome location | Description |
|---|---|---|---|---|---|
| Decreased expression in Prader–Willi syndrome | |||||
| SNRPN | −68.8 | 1.65E-08 | NM_003097 | 15q11.2 | Small nuclear ribonucleoprotein polypeptide N |
| PAR1 | −32.4 | 3.22E-05 | BE783065 | 15q11.2 | Prader–Willi/Angelman region-1 |
| Transcript | −18.7 | 2.88E-04 | AL520272 | 12q13.13 | Hypothetical gene |
| PLOD2 | −10.2 | 5.25E-04 | NM_000935 | 3q23-q24 | Procollagen-lysine, 2-oxoglutarate 5-dioxygenase |
| IGLJ3 | −8.9 | 4.73E-04 | X79782 | 22q11.1-q11.2 | IG lambda light chain |
| IPW | −6.8 | 4.45E-05 | AI672541 | 15q11-q12 | Imprinted in Prader–Willi |
| CNN3 | −4.9 | 5.50E-04 | AI807004 | 1p22-p21 | Calponin 3, acidic |
| LUC7A | −2.6 | 2.08E-04 | AA005430 | 17q21 | Cisplatin resistance-associated overexpressed protein |
| DKFZp762A217 | −2.0 | 7.51E-04 | AI765006 | 12q21.31 | Hypothetical protein DKFZp762A217 |
| PPP1R10 | −2.0 | 3.71E-06 | AI492873 | 6p21.3 | Protein phosphatase 1, regulatory subunit 10 |
| USP6 | −2.0 | 6.16E-04 | AA291110 | 17q11 | Ubiquitin specific protease 6 |
| PNAS-4 | −2.0 | 6.34E-04 | AK025651 | 1q44 | CGI-146 protein |
| Transcript | −1.9 | 9.08E-05 | BE675040 | Transcribed sequence | |
| TIMM22 | −1.9 | 2.61E-05 | H87708 | 17p13 | Translocase of inner mitochondrial membrane 22 homolog |
| Transcript | −1.8 | 1.72E-04 | AI669022 | 3q26.32 | transcribed sequences |
| Transcript | −1.8 | 3.46E-04 | AF085995 | 4q27 | CDNA FLJ42757 |
| C20orf14 | −1.8 | 5.95E-04 | AB019219 | 20q13.33 | Chromosome 20 open reading frame 14 |
| IPP | −1.8 | 5.21E-04 | NM_005897 | 1p34-p32 | Intracisternal A particle-promoted polypeptide |
| HNRPU | −1.7 | 4.35E-05 | D13413 | 1q44 | Tumor-associated 120 kDa nuclear protein |
| MHC2TA | −1.7 | 4.73E-04 | NM_000246 | 16p13 | MHC class II transactivator |
| DKFZp566O084 | −1.7 | 1.25E-04 | NM_015510 | 17p12 | DKFZP566O084 protein |
| FNBP3 | −1.7 | 6.05E-04 | AA176247 | 2q24.1 | Formin binding protein 3 |
| MAN1B1 | −1.6 | 8.43E-04 | AA631254 | 9q34 | Mannosidase, alpha, class 1B, member 1 |
| PPP2R1B | −1.6 | 5.84E-04 | AW009884 | 11q23.2 | Protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform |
| SENP1 | −1.6 | 7.42E-04 | AW665440 | 12q13.1 | SUMO1/sentrin specific protease 1 |
| ELAC2 | −1.6 | 4.01E-04 | NM_018127 | 17p11.2 | elaC homolog 2 |
| RBM17 | −1.6 | 2.26E-04 | BF063156 | 10p15.1 | RNA binding motif protein 17 |
| IL28RA | −1.5 | 2.68E-04 | AW340139 | 1p36.11 | mRNA sequence contains element MER30 repetitive element |
| PES1 | −1.5 | 5.84E-04 | NM_014303 | 22q12.1 | Pescadillo homolog 1, containing BRCT domain |
| ASH1L | −1.5 | 3.95E-04 | AI806500 | 1q22 | ash1 (absent, small, or homeotic)-like |
| Increased expression in Prader–Willi syndrome | |||||
| SRRM2 | +4.3 | 9.00E-05 | AC004493 | 16p13.3 | Serine/arginine repetitive matrix 2 |
| Transcript | +2.2 | 3.41E-04 | AC007228 | 19q13.43 | Transcribed sequence |
| Transcript | +2.1 | 7.49E-04 | AI869296 | 19q13.42 | Transcribed sequence |
| RREB1 | +2.1 | 2.08E-04 | BF591556 | 6p25 | ras responsive element binding protein 1 |
| FXYD3 | +2.0 | 2.19E-04 | NM_005971 | 19q13.13 | FXYD domain containing ion transport regulator 3 |
| Transcript | +2.0 | 7.40E-05 | BC015876 | 12q13.3 | Homo sapiens cDNA clone IMAGE:4715948, partial cds. |
| Transcript | +1.9 | 2.88E-04 | AI760978 | 15q26.3 | Similar to RIKEN cDNA |
| Transcript | +1.9 | 5.52E-04 | BC035102 | 10q21.3 | Clone IMAGE:5262215, mRNA |
| Transcript | +1.9 | 1.58E-04 | AW080025 | 12q13.3 | Transcribed sequences |
| E2F5 | +1.8 | 3.35E-05 | AW139195 | 8q21.2 | E2F transcription factor 5, p130-binding |
| SDAD1 | +1.7 | 2.91E-04 | AA768015 | 4q21.21 | Hypothetical protein FLJ10498 |
| POLR2C | +1.7 | 6.31E-04 | AJ224143 | 16q13-q21 | Polymerase (RNA) II (DNA directed) polypeptide C |
| FLJ10846 | +1.7 | 3.53E-04 | NM_018241 | 4q31.22 | Hypothetical protein FLJ10846 |
| OFD1 | +1.7 | 1.51E-04 | AW292752 | Xp22.2-p22.3 | Oral-facial-digital syndrome 1 |
| FLJ14082 | +1.7 | 3.13E-04 | NM_025024 | 2q11.2 | Hypothetical protein |
| SCAMP5 | +1.6 | 6.28E-04 | BE222801 | 15q23 | mRNA sequence contains TAR1 repetitive element |
| CRELD1 | +1.5 | 4.71E-04 | NM_015513 | 3p25.3 | Cysteine-rich with EGF-like domains 1 |
| UBAP1 | +1.5 | 1.46E-04 | AL136733 | 9p22-p21 | Ubiquitin-associated protein 1 |
| CDC5L | +1.5 | 1.93E-04 | AB007892 | 6p21 | CDC5 cell division cycle 5-like |
| Transcript | +1.5 | 8.36E-05 | AK026869 | 3p25.1 | Transcribed sequence |