Table 3.
MRI was performed at rest and during dobutamine stress in 15 patients with PH and five younger volunteers. Thirteen 15 PH participants with evaluable ΔRAC are dichotomized around the median (−2.6%). Values are median (range). Statistically significant differences between low and high ΔRAC groups are highlighted.
| Low ΔRAC | High ΔRAC | Younger volunteers | |
|---|---|---|---|
| Stress PA | |||
| ΔRAC (%) | −6.4 (−14.6–−3.1)* | 3.4 (−2.1–8.4) | 37.2 (21.4–152.0) |
| ΔAMAX (cm2) | 0.23 (−0.53–0.78) | 0.32 (0.01–0.54) | 0.82 (−1.04–1.33) |
| ΔAMIN (cm2) | 0.67 (0.36–1.09)* | 0.04 (−0.01–0.52) | −0.01 (−1.80–0.22) |
| Stress RV | |||
| ΔSVI (%) | −2 (−21–43) | 15 (−3–116) | 22 (0–43) |
| ΔEF (%) | 1 (−25–54) | 17 (−8–227) | 46 (4–62) |
| ΔHR (%) | 51 (30–114) | 30 (10–56) | 49 (28–89) |
| RV-PA coupling | |||
| η'vv REST | 0.51 (0.11–1.26) | 0.46 (0.16–0.89) | 1.69 (1.01–2.30) |
| η'vv STRESS | 0.80 (0.09–2.52) | 0.66 (0.21–1.69) | 4.86 (2.81–6.13) |
| Resting hemodynamics | |||
| PVR (mmHg/L/min) | 11 (8–19) | 9.5 (7–23) | NR |
| sPAP (mmHg) | 92 (76–132) | 70 (38–112) | NR |
| PAPP (mmHg) | 61 (52–84) | 40 (26–76) | NR |
| MVO2 (%) | 63 (60–76) | 63 (53–70) | NR |
PA, pulmonary artery; RV, right ventricle; RAC, relative area change; RV, right ventricle; AMAX; maximum PA area; AMIN, minimum PA area; SVI, stroke volume index; EF, ejection fraction; HR, heart rate; PVR, pulmonary vascular resistance; sPAP, systolic pulmonary artery pressure; MVO2, mixed venous oxygen saturation; η'vv, RV stroke volume/RV end-systolic volume ratio; NR, not recorded.
*
P < 0.01 (low ΔRAC vs. high ΔRAC).